PrimaGen Advanced™ Allograft

Recreating the benefits of the Gold Standard while reducing the drawbacks.

The Complete Bone Remodeling Triad

A fresh frozen allograft, which is cryopreserved and processed using a proprietary processing method to retain endogenous components of the native bone that support bone healing.

PrimaGen Advanced Allograft possesses all three components of the bone healing triad: osteoconductivity, osteoinductivity, and osteogenicity. The combination of morselized cancellous bone and demineralized cortical bone provides a bone grafting scaffold.7

System Features

PrimaGen Advanced™ Allograft has been developed to overcome the limitations of other bone graft substitutes and designed to offer a real alternative to autograft.

Streamline Your Procedures with an Advanced Delivery System

PrimaGen Advanced™ Allograft is packaged in an intuitive, proprietary pre-filled delivery syringe and features a built-in filter that allows for the full preparation of the material directly inside the syringe.

The Complete Bone Remodeling Triad

This allograft retains osteoconductive and osteoinductive properties as well as naturally inherent osteogenic cells.


  • Cortical bone is processed into a fiber-like structure and demineralized, retaining a variety of osteoinductive protein important for bone formation.
  • The cancellous bone tissue is morselized into particulate, creating a consistent graft.

The PrimaGen Advanced Allograft Process

  • The advanced, proprietary processing methods protect and retain the naturally inherent osteogenic cells.
  • At least 750,000 cells/cc of cancellous tissue with at least 70% cell viability1.
  • Cells include MSCs, osteoprogenitor cells and pre-osteoblasts.


  • PrimaGen Advanced Allograft Options

    1cc, 5cc, 10cc, 15cc.

Related Products

HIGHRIDGE Spine utilizes its deep industry knowledge and expertise to refine a comprehensive anterior cervical product portfolio of next generation devices.



PrimaGen Advanced™ Allograft Brochure

07471 US REV 10/16 Download PDF

Total Cervical Solutions Brochure

ZV0396 REV A 01/23 (U.S.)Download PDF

Additional Information

  • Contact Us

    USA: 720-894-9016

    To submit a complaint, please email

    10225 Westmoor Dr. Westminster, CO 80021 USA

    To obtain a copy of the current Instructions for Use (IFU) for full prescribing and risk information, please call 720-894-9016.

  • References

    1. Khan SN, Cammisa FP Jr, Sandhu HS, Diwan AD, Girardi FP, Lane JM. The biology of bone grafting. J AM Acad Orthop Surg. 2005;13(1):77–86. 
    2. Han B, Tang B, Nimni ME. Quantitative and sensitive in vitro assay for osteoinductive activity of demineralized bone matrix. J Orthop Res. 2003;21(4):648–54. 
    3. Pietrzak WS, Woodell-May J, McDonald N. Assay of bone morphogenetic protein -2, -4 and -7 in human demineralized bone matrix. J Craniofac Surg. 2006;17(1):84–90. 
    4. Wildemann B, Kadow-Romacker A, Haas NP, Schmidmaier G. Quantification of various growth factors in different demineralized bone matrix preparations. J Biomed Mater Res A. 2007;81(2):437–42. 
    5. American Association of Tissue Banks. Standards for Tissue Banking, 14th ed. McLean, VA: American Association of Tissue Banks, 2016.
  • Legal Manufacturer

    Zimmer Biomet Spine, Inc.

    10225 Westmoor Dr.

    Westminster, CO 80021 USA